Thermo Fisher Scientific PPP2R2B Polyclonal Antibody
PPP2R2B 단백질에 특이적인 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 사용 가능. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C 보관, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), beta isoform |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Rabbit, Pig, and Orangutan
Target Information
The PPP2R2B gene encodes a beta isoform of the regulatory subunit B55 subfamily of protein phosphatase 2 (PP2A), a key Ser/Thr phosphatase involved in negative regulation of cell growth and division.
PP2A consists of a catalytic subunit and a constant regulatory subunit that associates with various regulatory subunits, modulating substrate selectivity and catalytic activity.
Mutations in PPP2R2B are associated with autosomal dominant spinocerebellar ataxia 12 (SCA12), characterized by cerebellar degeneration and impaired motor coordination.
Multiple alternatively spliced variants exist, some containing a CAG trinucleotide repeat expansion (66–78 copies) in SCA12 cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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