Thermo Fisher Scientific PPP2R2B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Rat, Bovine, Rabbit, Pig, and Orangutan

Target Information

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is involved in the negative control of cell growth and division. It consists of a catalytic subunit and a constant regulatory subunit that associates with various regulatory subunits. The B regulatory subunit modulates substrate selectivity and catalytic activity.
This gene encodes the beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), characterized by cerebellar degeneration and impaired coordination of speech and movement. Multiple alternatively spliced variants encoding different isoforms have been identified. Some variants include a CAG trinucleotide repeat sequence (7–28 copies) that can expand to 66–78 copies in SCA12 cases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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