Thermo Fisher Scientific Actin, Skeletal Muscle Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Positive control: Skeletal muscle
• Cellular location: Cytoplasmic

Target Information

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved and play key roles in cell motility, structure, and integrity. Alpha, beta, and gamma actin isoforms have been identified:

• Alpha actins: major constituent of the contractile apparatus
• Beta and gamma actins: involved in regulation of cell motility

This actin is an alpha actin found in skeletal muscle.
Mutations in this gene cause:

• Nemaline myopathy type 3
• Congenital myopathy with excess of thin myofilaments
• Congenital myopathy with cores
• Congenital myopathy with fiber-type disproportion

These diseases lead to muscle fiber defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.