Thermo Fisher Scientific MMP-14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MMP-14. Validated for WB, IHC(P), and ICC/IF applications. High specificity and affinity purified. Suitable for detecting membrane-associated MMP-14 in various tissues. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the internal segment of human MMP-14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human breast carcinoma
- Cellular location: Membrane, Melanosome
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in pathological conditions including arthritis and metastasis.
Most MMPs are secreted as inactive proproteins that are activated upon cleavage by extracellular proteinases. MMP-14 belongs to the membrane-type MMP (MT-MMP) subfamily, which contains a transmembrane domain indicating cell surface expression. MMP-14 activates MMP2, contributing to tumor invasion processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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