Thermo Fisher Scientific ARPP21 Polyclonal Antibody

Thermo Fisher Scientific ARPP21 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ARPP21.

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci designated spinocerebellar ataxia (SCA) 1, 2, 3, 4, and 6, assigned to five different chromosomes.
ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII, often referred to as the ‘pure’ cerebellar syndrome (SCA5), are most likely homogeneous disorders.
Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein.
The expanded repeats are variable and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
This locus has been mapped to chromosome 6, and the diseased allele contains 41–81 CAG repeats compared to 6–39 in the normal allele, associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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