Thermo Fisher Scientific CLIP1 Polyclonal Antibody
CLIP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, -20°C 보관.
- 카탈로그번호
- PA5101483
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CLIP1 (Accession P30622), corresponding to amino acid residues C1384–D1434 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850918 |
Product Specific Information
Antibody detects endogenous levels of total CLIP1.
Target Information
CLIP170 was initially identified as a new type of intermediate filament-associated protein highly expressed in Reed–Sternberg cells, the tumoral cells diagnostic for Hodgkin’s disease. Later studies revealed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles.
CLIP170 also interacts with LIS1, a protein involved in brain development, to regulate dynein/dynactin binding to microtubules.
Further research suggests that CLIP170 influences lamellipodia formation and cell invasion in invasive breast cancer cells by modulating the release of kinesin and IQGAP1 from a complex containing CLIP170 and Rac1.
At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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