Thermo Fisher Scientific PNPase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondrial) is an RNA-binding protein involved in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3′ overhang double-stranded RNA in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. PNPT1 also functions as a cytoplasmic RNA import factor, contributes to mitochondrial morphogenesis and respiration, regulates expression of the electron transport chain, and stabilizes specific mature miRNAs in melanoma cells. Mutations can cause combined oxidative phosphorylation deficiency 13 (COXPD13) and autosomal recessive deafness 70 (DFNB70).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.