Thermo Fisher Scientific PHAX Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PHAX protein. Validated for Western blot and immunoprecipitation. Supplied as liquid at 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 344 and 394 of human Phosphorylated Adaptor for RNA Export (PHAX) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
PHAX is a phosphoprotein adapter involved in XPO1-mediated U snRNA export from the nucleus. It bridges the cap binding complex (CBC)-bound snRNA and the GTPase Ran in its active GTP-bound form together with export receptor XPO1. Phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while dephosphorylation in the cytoplasm causes export complex disassembly. PHAX is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. It binds strongly to m7G-capped U1 and U5 snRNAs, and also plays a role in the biogenesis and transport of U3 snoRNA and other small nucleolar RNAs. Additionally, it binds to telomerase RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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