Thermo Fisher Scientific PNPase Polyclonal Antibody
Rabbit polyclonal antibody targeting human PNPase (PNPT1). Validated for WB and IP applications. Predicted cross-reactivity with mouse. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 700 and 750 of Human Polynucleotide Phosphorylase 1 (PNPase) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse.
Target Information
PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondrial) is an RNA-binding protein involved in multiple RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades double-stranded RNA with 3′ overhangs in an ATP-dependent manner. It is required for proper processing and polyadenylation of mitochondrial mRNAs.
PNPT1 also functions as a cytoplasmic RNA import factor, plays roles in mitochondrial morphogenesis, respiration, and regulation of electron transport chain expression. It contributes to the stability of specific mature miRNAs in melanoma cells and RNA surveillance.
Mutations in this gene are associated with combined oxidative phosphorylation deficiency 13 (COXPD13) and autosomal recessive deafness 70 (DFNB70).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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