Thermo Fisher Scientific GGCX Polyclonal Antibody
Thermo Fisher Scientific의 GGCX Polyclonal Antibody는 인간 및 마우스 시료에 반응하는 rabbit polyclonal 항체로, Western blot과 ELISA에 적합합니다. 비결합형 액상 형태이며, PBS와 글리세롤 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 479–758 of human GGCX (NP_000812.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914179 |
Product Specific Information
- Positive test controls: LO2, MCF7, HeLa, Mouse liver
- Subcellular localization: Endoplasmic reticulum membrane, Multi-pass membrane protein
Immunogen sequence:
QRIFDPRVDI VQAAWSPFQR TSWVQPLLMD LSPWRAKLQE IKSSLDNHTE VVFIADFPGL HLENFVSEDL GNTSIQLLQG EVTVELVAEQ KNQTLREGEK MQLPAGEYHK VYTTSPSPSC YMYVYVNTTE LALEQDLAYL QELKEKVENG SETGPLPPEL QPLLEGEVKG GPEPTPLVQT FLRRQQRLQE IERRRNTPFH ERFFRFLLRK LYVFRRSFLM TCISLRNLIL GRPSLEQLAQ EVTYANLRPF EAVGELNPSN TDSSHSNPPE SNPDPVHSEF
Target Information
GGCX (gamma-glutamyl carboxylase)
Also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), GGCX is a 758 amino acid multi-pass membrane protein localized to the endoplasmic reticulum membrane. It catalyzes vitamin K-dependent carboxylation of glutamate residues on target proteins, forming calcium-binding gamma-carboxyglutamate (Gla) residues while converting vitamin K to vitamin K epoxide.
GGCX functions as a monomer and is essential for the activity of all vitamin K-dependent proteins, including those involved in blood coagulation and bone matrix formation.
Defects in the GGCX gene are associated with combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, both leading to abnormal skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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