Thermo Fisher Scientific PTPN2 Polyclonal Antibody
PTPN2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity 정제, 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 세포막, 세포질, 핵 등 다양한 세포 위치에서 검출 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–353 of human PTPN2 (NP_536348.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914180 |
Product Specific Information
- Positive test controls: SW480, BT-474, Jurkat, K-562
- Localization: Cell membrane, Cytoplasm, Endoplasmic reticulum, ER-Golgi intermediate compartment, Nucleus
Immunogen sequence:
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSERPRL TDT
Target Information
T-cell protein tyrosine phosphatase (TC-PTP, also known as PTPT and PTPN2) is an enzyme that removes phosphate groups from tyrosine residues in proteins.
It has two splice variants with distinct subcellular localizations:
- 45 kDa isoform: Nuclear in resting cells; redistributes to cytosol upon stimulation.
- 48 kDa isoform: Found in the endoplasmic reticulum with different physiological substrates.
TC-PTP is expressed in many tissues, particularly in hematopoietic cells. Knockout mice lacking TC-PTP exhibit erythropoietic and lymphopoietic deficits, indicating its critical role in bone marrow maturation.
It dephosphorylates various phosphoproteins, including p52 Shc, and receptors for EGF, insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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