Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 인간, 개, 쥐, Xenopus 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 세포골격 연구 및 MYH9 관련 질환 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1949–1960 of human nonmuscle myosin IIA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 10.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_795005 |
Product Specific Information
Recommended positive controls: MDCK, Jurkat, NRK.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons encoding a 1,960 amino acid protein. This protein forms a hexameric complex with two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape. Mutations in MYH9 cause autosomal dominant disorders known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a key role in hematopoiesis, where its proper function is necessary for hematopoietic stem and progenitor cell survival. Loss of MYH9 disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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