Thermo Fisher Scientific Cofilin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

Assay-dependent

-

Immunocytochemistry (ICC/IF)

1:1,000

-

Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, conjugated to maleimide-activated KLH, corresponding to residues 154-166 of human cofilin with an N-terminal added cysteine. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cofilin,uniProtId:P23528-1,ncbiNodeId:9606,antigenRange:154-166,antigenLength:166,antigenImageFileName:PA1-24931_Cofilin_P23528-1_Rabbit.svg,antigenImageFileNamePDP:PA1-24931_Cofilin_P23528-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

11.4 mg/mL

Purification

IgG fraction

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779863

Product Specific Information

Recommended positive controls: A431, PC-12, NIH3T3, MDCK.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.