Thermo Fisher Scientific MYO5A Polyclonal Antibody
Rabbit polyclonal antibody targeting MYO5A, validated for WB and ICC/IF. Detects myosin V heavy-chain protein involved in vesicle transport. Supplied as liquid, 1 mg/mL, unconjugated. Recommended for use with MDCK and NRK cells. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:75 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an epitope within the C-terminal of human Myosin VI, with N-terminal cysteine added, conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2148472 |
Product Specific Information
- Recommended positive controls: MDCK, NRK
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The MYO5A gene encodes one of three myosin V heavy-chain proteins within the myosin gene superfamily. Myosin V functions as an actin-based motor protein involved in cytoplasmic vesicle transport, spindle-pole alignment, and mRNA translocation. It is highly expressed in melanocytes and nerve cells. Mutations in MYO5A are associated with Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3), and neuroectodermal melanolysosomal disease (Elejalde disease). Multiple alternatively spliced transcript variants exist, though some full-length forms remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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