Thermo Fisher Scientific LDLR Polyclonal Antibody
LDLR 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC 등 다양한 응용 가능. 인간과 마우스 반응성 확인, 원숭이에도 예측 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to an internal portion of the human LDLR protein (within residues 500–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152478 |
Product Specific Information
- Predicted to react with monkey based on 100% sequence homology.
- 92% sequence homology with mouse.
Target Information
The low density lipoprotein receptor (LDLR) gene family encodes cell surface proteins responsible for receptor-mediated endocytosis of specific ligands. LDL binds to the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for feedback regulation of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Mutations in the LDLR gene cause familial hypercholesterolemia. LDLR, along with SCARB1, CLDN1, and CD81, is also implicated as an entry factor for Hepatitis C virus. At least three isoforms of LDLR are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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