Thermo Fisher Scientific SPG11 Polyclonal Antibody
SPG11 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. Human, Mouse, Rat 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.02% sodium azide를 포함하며, 2–8°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid synthetic peptide near the carboxy terminus of human SPG11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157031 |
Product Specific Information
- Suggested positive control: mouse heart tissue lysate
- PA5-20683 can be used with blocking peptide PEP-0799.
Target Information
Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.
Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a frequent form of complicated hereditary spastic paraplegia (cHSP), characterized by mental retardation and muscle stiffness at onset, followed by slowly progressive paraparesis and cognitive deterioration.
Mutations in the SPG11 gene encoding the spatacsin protein are a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein phosphorylated upon DNA damage and is highly expressed in the cerebellum.
SPG11 mutations are more frequent in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is associated with mutations in both SPG15 and SPG11 genes.
Recent studies indicate that Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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