Thermo Fisher Scientific PDCD5 Polyclonal Antibody
PDCD5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 보관 가능하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide from near the amino terminus of human PDCD5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155020 |
Product Specific Information
- A suggested positive control is Jurkat cell lysate.
- PA5-20684 can be used with blocking peptide PEP-0800.
Target Information
Programmed cell death 5 (PDCD5), a human apoptosis-related protein, plays an early and universal role in apoptosis. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, where it rapidly translocates from the cytoplasm to the nucleus. It has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are crucial for its apoptosis-promoting and translocation abilities. PDCD5 enhances TAJ/TROY-induced paraptosis-like cell death and acts as a Tip60 co-activator in the Tip60 pathway. Nucleotide polymorphisms in the PDCD5 promoter region may influence leukemia and lung cancer susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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