Thermo Fisher Scientific Phospho-PERK (Thr982) Polyclonal Antibody
Phospho-PERK (Thr982) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PERK 신호전달 연구 및 스트레스 반응 경로 분석에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 10 publications |
| Immunohistochemistry (IHC) | 1:100–1:300 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PERK around the phosphorylation site of T982 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576881 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis.
In the case of EIF2AK3, signaling is initiated by misfolded proteins in the endoplasmic reticulum (ER).
Defects in EIF2AK3 cause Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus.
WRS is a rare autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation, and other multisystem manifestations such as hepatic and renal dysfunctions, mental retardation, and cardiovascular abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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