Thermo Fisher Scientific Phospho-ITK (Tyr512) Polyclonal Antibody
Phospho-ITK (Tyr512) 폴리클로날 항체로 인간 및 마우스 반응성. Western blot, IHC, ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체. T세포 신호전달 연구에 적합하며 -20°C에서 안정적으로 보관 가능.
- 카탈로그번호
- PA540292
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-ITK (Tyr512) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100–1:300 | - |
| ELISA | 1:5,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Emt around the phosphorylation site of Y512 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608041 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation.
The Tec family of non-receptor tyrosine kinases is composed of six proteins: Tec, Itk (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk), and Dsrc28C.
All members of the family contain SH3 and SH2 domains and, except for Txk and Dsrc28C, also possess pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini.
Itk associates with CD28 and becomes activated subsequent to CD28 ligation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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