Thermo Fisher Scientific MYH9 Monoclonal Antibody (GT566)
MYH9 단백질을 인식하는 Mouse monoclonal antibody (Clone GT566). Western blot 및 IHC(P)에서 검증됨. Human과 Mouse에 반응하며, 단백질 A로 정제된 1 mg/mL 액상 시약. 세포 골격 연구 및 MYH9 관련 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT566 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MYH9 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735283 |
Product Specific Information
- Positive Control: HeLa, MYH9-transfected 293T
- Predicted Reactivity: Mouse (100%), Rat (100%), Dog (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton involved in cell migration, adhesion, division, and shape maintenance.
It spans over 106 kilobases with 41 exons encoding a 1,960 amino acid protein forming a hexameric complex (two heavy chains, two regulatory light chains, and two essential light chains).
Mutations in MYH9 cause a group of autosomal dominant disorders known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These conditions are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a crucial role in hematopoiesis, where its proper function is essential for the maintenance of hematopoietic stem and progenitor cells. Loss of MYH9 function disrupts normal hematopoiesis, leading to blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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