Thermo Fisher Scientific Phospho-Tau (Ser416) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: NIH/3T3
• Immunogen Sequence: TGSID

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, functioning as a linker between them. Tau localization defines axonal polarity, and its isoforms contribute to cytoskeletal plasticity and stabilization.

In its hyperphosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions found in Alzheimer’s disease brains. Hyperphosphorylation impairs microtubule binding, leading to destabilization and neuronal degeneration. Tau is phosphorylated by kinases such as GSK-3β, PKA, CDK5, and casein kinase II. Abnormal phosphorylation of Tau is also observed in other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.