Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Cellular location: axon, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytosol, dendrite, mitochondrion, neuron projection, nucleus, perikaryon, perinuclear region of cytoplasm, smooth endoplasmic reticulum, synaptic vesicle, terminal bouton
• Immunogen sequence: RQSLI

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with its cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.
In humans, four splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
TH dysfunction is associated with neurological and cardiovascular disorders such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular diseases.

주의사항

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.