Thermo Fisher Scientific MUC1 Polyclonal Antibody
MUC1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ICC/IF 등 다양한 응용에 적합하며 Human 및 Mouse 시료에 반응. 합성 펩타이드 면역원 사용, 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태로 제공.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:200 | - |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from cytoplasmic tail of human MUC-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.6, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987121 |
Product Specific Information
PA5-16847 targets MUC-1 in IHC (P) applications and shows reactivity with Human and Mouse samples.
The immunogen is a synthetic peptide from the cytoplasmic tail of human MUC-1 protein.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and certain hematopoietic lineages.
It is a transmembrane glycoprotein with a large extracellular domain processed through proteolysis and extensive O-linked glycosylation.
MUC1 is highly polymorphic, with alleles encoding 30–90 tandem repeats, resulting in variable molecular weights.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Transgenic MUC1 associates with all four erbB receptors and localizes with EGFR in lactating glands.
Aberrant expression and glycosylation of MUC1 are linked to carcinomas.
Multiple alternatively spliced variants exist, though only some full-length forms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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