Thermo Fisher Scientific PGP9.5 Polyclonal Antibody
Rabbit polyclonal antibody against human PGP9.5 (UCH-L1). Validated for WB, IHC(P), and ICC/IF applications. Useful neuronal marker for neurodegenerative disease research. Supplied in liquid form, 0.24 mg/mL concentration.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human PGP9.5 protein (amino acids 1–223, UniProt ID: P09936-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.24 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986012 |
Product Specific Information
PA5-16825 targets Protein Gene Product 9.5 (PGP9.5) in IHC (P) applications and shows reactivity with human samples.
The immunogen used is recombinant full-length human PGP9.5 protein.
Target Information
PGP9.5 (Protein Gene Product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of approximately 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12).
PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers. It is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells.
Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases.
Because of its neuronal specificity, PGP9.5 serves as a valuable marker for neuronal studies and neurodegenerative disease research, including Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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