Thermo Fisher Scientific PGP9.5 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA5-16825 targets Protein Gene Product 9.5 (PGP9.5) in IHC (P) applications and shows reactivity with human samples.
The immunogen used is recombinant full-length human PGP9.5 protein.

Target Information

PGP9.5 (Protein Gene Product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of approximately 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12).
PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers. It is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells.
Overexpression of PGP9.5 is associated with non-small cell lung cancer, while decreased expression is linked to Huntington’s and Alzheimer’s diseases.
Because of its neuronal specificity, PGP9.5 serves as a valuable marker for neuronal studies and neurodegenerative disease research, including Parkinson’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.