Thermo Fisher Scientific Cerebellin 2 Polyclonal Antibody
Rabbit polyclonal antibody specific to human and rat Cerebellin 2. Validated for Western blot applications. Detects endogenous 24 kDa protein. High purity (>95%) and affinity purified. Supplied in PBS with 50% glycerol for stable storage.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 170–222 of human Cerebellin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553538 |
Product Specific Information
- Detects endogenous Cerebellin 2 protein (~24 kDa).
- Purity >95% by SDS-PAGE.
Target Information
Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from the precursor Cerebellin 1 (Cbln1). The Cerebellin family includes Cbln1, Cbln2, Cbln3, and Cbln4, belonging to the C1q protein family. These proteins act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
Cerebellin and its metabolite des-Ser(1)Cer are also expressed in extra-cerebellar tissues, including the adrenal gland. Cerebellin 1, 2, and 3 form homo- and heteromeric complexes, influencing each other’s degradation and secretion. Cerebellin 3 cannot form homomeric complexes and is secreted only when complexed with Cerebellin 1. Decreased Cerebellin levels have been observed in patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting its involvement in disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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