Thermo Fisher Scientific Cerebellin 4 Polyclonal Antibody
Cerebellin 4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 148–197 of human Cerebellin 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553539 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of approximately 27 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1 (precerebellin 1 or Cbln1).
The precerebellin subfamily includes Cerebellin 1, 2 (Cbln2), 3 (Cbln3), and 4 (Cbln4), which belong to the C1q protein family.
These proteins act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
Cerebellin and its metabolite des-Ser(1)Cer are also expressed in extra-cerebellar tissues such as the adrenal gland.
Cerebellin 1, 2, and 3 can form homo- and heteromeric complexes influencing each other’s degradation and secretion, whereas Cerebellin 3 requires Cerebellin 1 for secretion.
Reduced Cerebellin levels have been observed in patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting its role in disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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