Thermo Fisher Scientific ERAS Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: References

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 25 kDa.
• Purity >95% by SDS-PAGE.

Target Information

The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2) with several base substitutions in coding regions, but was later described as potentially encoding a functional human ERAS protein.
The ERAS oncogene supports tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein.
ERAS protein shares less than 50% amino acid identity with H-Ras, another Ras family member, but retains key conserved domains essential for Ras function. It also contains amino acid residues identical to those present in active mutants of Ras, causing oncogenic transformation in NIH 3T3 cells.
The human ERAS gene is localized in the chromosomal region Xp11.23.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.