Thermo Fisher Scientific ERAS Polyclonal Antibody
ERAS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot 및 Immunocytochemistry에 사용 가능하며, Human, Mouse, Rat에 반응합니다. 고순도(>95%) 항원 친화 크로마토그래피 정제 제품으로, 연구용으로 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 181–233 of Human E-Ras |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553534 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 25 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2) with several base substitutions in coding regions, but was later described as potentially encoding a functional human ERAS protein.
The ERAS oncogene supports tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein.
ERAS protein shares less than 50% amino acid identity with H-Ras, another Ras family member, but retains key conserved domains essential for Ras function. It also contains amino acid residues identical to those present in active mutants of Ras, causing oncogenic transformation in NIH 3T3 cells.
The human ERAS gene is localized in the chromosomal region Xp11.23.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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