Thermo Fisher Scientific Protein Z Monoclonal Antibody (OTI4F1)
Protein Z 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot 및 IHC(Paraffin) 검증 완료. Human 시료 반응성, 비결합형(Unconjugated) 액상 항체. PBS 기반 완충액에 보관하며 -20°C에서 냉동 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 115–400 of PROZ produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725117 |
Target Information
Protein Z (PROZ) is a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 62 kDa and composed of 396 amino acids. It contains four domains: a Gla-rich region, two EGF-like domains, and a trypsin-like domain. Although structurally related to serine proteases in the coagulation cascade (factors VII, IX, X, and protein C), Protein Z lacks the catalytic serine residue and is therefore not enzymatically active.
Protein Z plays a regulatory role in the coagulation cascade by accelerating the degradation of factor Xa through the protein Z-related protease inhibitor (ZPI), enhancing the reaction up to 1000-fold. It also participates indirectly in factor XI degradation. Deficiency in Protein Z has been variably associated with thrombosis or bleeding tendencies.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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