Thermo Fisher Scientific DCLK1 Monoclonal Antibody (OTI1F8)
DCLK1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 IgG2b 아이소타입입니다. 고순도의 액상 항체로 -20°C 보관 조건에서 안정적입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
- Publications: View references
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
- Publications: View references
Immunocytochemistry (ICC/IF)
- Tested Dilution: —
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 193–492 of DCLK1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724193 |
Target Information
DCAMKL1 (DCLK1) serine/threonine kinase, also known as doublecortin-like kinase 1, contains two N-terminal doublecortin domains that bind microtubules and regulate their polymerization.
It also includes a C-terminal serine/threonine protein kinase domain homologous to Ca²⁺/calmodulin-dependent protein kinase, and a serine/proline-rich domain mediating multiple protein-protein interactions.
DCAMKL1 is a microtubule-associated kinase capable of autophosphorylation and has microtubule-polymerizing activity independent of its kinase function.
It plays roles in neuronal migration, retrograde transport, neuronal apoptosis, and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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