Thermo Fisher Scientific ATXN10 Polyclonal Antibody
ATXN10 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 합성 펩타이드 면역원으로 제작되었습니다. 친화 크로마토그래피로 정제되었으며, PBS/glycerol 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATXN10 (Accession Q9UBB4), corresponding to amino acid residues L11–V61 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852957 |
Product Specific Information
Antibody detects endogenous levels of total ATXN10.
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying degrees of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy.
- ADCA I: presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia
- ADCA II: presence of retinopathy
- ADCA III: absence of associated signs
Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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