Thermo Fisher Scientific Huntingtin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Neoepitope antibodies are designed to recognize smaller cleaved fragments or processed forms of proteins rather than the intact precursor form.
Human HTT caspase cleavage sites generate fragment-specific forms of the protein. Caspase-3/7 has been shown to generate cleavage sites at amino acids 513 and 552. Caspase-2 cleaves at amino acid 552, and caspase-6 at amino acid 586.
Neo-specific antibody PA1-003 recognizes the 552 cleaved fragment without detecting the full-length form.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms with different abundance in fetal and adult tissues.
The larger transcript (~13.7 kb) is predominantly expressed in adult and fetal brain, while the smaller transcript (~10.3 kb) is more widely expressed.
The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA properties or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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