Thermo Fisher Scientific DMPK Polyclonal Antibody
DMPK 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등에 사용 가능. 인간 시료에 반응하며, 액상 형태로 제공됨. Affinity chromatography로 정제되었으며, -20°C에서 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DMPK (Accession Q09013), corresponding to amino acid residues L20–E40 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818204 |
Product Specific Information
This antibody detects endogenous levels of total DMPK.
Target Information
DMPK (Dystrophia Myotonica Protein Kinase) is a serine/threonine kinase expressed in various muscle and nerve tissues. Mutations in the untranslated region of the DMPK gene are characteristic of myotonic dystrophy. The encoded protein interacts with Rho family small GTPases and phosphorylates substrates such as myogenin, the β-subunit of L-type calcium channels, and phospholemman. Expansion of CTG trinucleotide repeats (50–5,000 copies) in the 3′ untranslated region causes myotonic dystrophy type I, with severity correlated to repeat number. Repeat expansion leads to chromatin condensation and altered gene expression in the region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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