Thermo Fisher Scientific HAS1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms, from bacteria to mammals. It is a major component of the extracellular matrix, consisting of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane and extruded into the extracellular space.

HA functions include:

• Space filling and joint lubrication
• Providing a matrix for cell migration
• Supporting wound healing and tissue repair
• Facilitating blood vessel and fibroblast ingrowth

Changes in HA concentration are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. The interaction of HA with the leukocyte receptor CD44 is important for tissue-specific homing of leukocytes, and overexpression of HA receptors correlates with tumor metastasis.

HAS1 is part of the vertebrate gene family encoding hyaluronan synthases and shows significant homology to the hasA gene product of Streptococcus pyogenes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.