Thermo Fisher Scientific Factor XIII Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 25 µg/mL

ELISA

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

PA1-43050 detects Factor XIII in human samples.
It has been successfully used in Western blot and ELISA applications.
PA1-43050 was derived from human Factor XIII.

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as carrier molecules without enzymatic activity. Platelet factor XIII consists only of two A subunits identical to those of plasma origin.

Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase, catalyzing gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules to stabilize the clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.

Factor XIII deficiency is classified into:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit alone

These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.