Thermo Fisher Scientific Protein C Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-43051 detects Protein C in human samples.
It has been successfully used in Western blot and ELISA applications.
PA1-43051 was derived from human Protein C.

Target Information

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex.
Activated Protein C contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII.
It is produced in the liver and composed of two polypeptide chains.
The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor, and the active enzyme (55 kDa) cleaves factor Va and VIIIa, thereby inhibiting blood coagulation.
Normal plasma concentrations are approximately 1–3 ng/mL for the active enzyme and 3 µg/mL for the proenzyme.
Mutations in the Protein C gene are associated with thrombophilia due to Protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.