Merck Anti-MCAM Antibody, clone P1H12

Anti-MCAM Antibody, clone P1H12

Clone Information

• Clone: P1H12
• Brand: Chemicon®
• Host: Mouse

Target Antigen

CD146 antigen (also known as):

• Cell surface glycoprotein P1H12
• Melanoma-associated antigen A32
• Melanoma-associated antigen MUC18
• S-endo 1 endothelial-associated antigen
• Melanoma adhesion molecule
• Melanoma cell adhesion molecule

Description

MUC18 antigen (CD146) is a member of the immunoglobulin superfamily and an intrinsic membrane glycoprotein of 110–120 kDa. It is found on the surface of endothelial cells, bone marrow fibroblasts, and various melanomas.
MUC18 has been used as a marker of tumor progression in human melanoma because its expression correlates strongly with poor prognosis and metastatic disease development.
Additionally, several human T, B, and myeloid leukemic cell lines express MUC18.
The close structural relationship with N-CAM and related molecules suggests that MUC18 may also function as a developmentally regulated cell adhesion molecule (Melanoma adhesion molecule or MCAM).

Specifications