Merck Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

Upstate®, from rabbit

acetyl-CoA carboxylase 1, acetyl-CoA carboxylase-alpha, acetyl-Coenzyme A carboxylase alpha

생물학적 소스

rabbit

Quality Level

100

항체 형태

purified antibody

antibody product type

primary antibodies

클론

polyclonal

species reactivity

canine, human

species reactivity (predicted by homology)

bovine (immunogen homology), chicken (immunogen homology), rat (immunogen homology), dog (immunogen homology), mouse (immunogen homology)

포장

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

NCBI 수납 번호

NP_942131

UniProt 수납 번호

Q13085

배송 상태

ambient

Acetyl CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes, whereas it is a large, multi-domain enzyme in most eukaryotes. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. Human genome contains the genes for two different ACCs - ACACA and ACACB. The activity of the enzyme is controlled by the reversible phosphorylation. The activities of the enzyme is inhibited if phosphorylated; the phosphorylation takes place when the hormones, glucagon or epinephrine bind to the receptors or the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase. The presence of fatty acid inhibits the activities of the enzyme. When insulin binds to its receptors of the cell, it activates a phosphatase to dephosphorylate the enzyme; the activities of the acetyl CoA carboxylase is thus enhanced. Acetyl CoA carboxylase has recently become a target in the design of new anti-obesity and antibiotic drugs.