Merck Anti-Dicer1 Antibody, clone 5D12.2

Anti-Dicer1 Antibody, clone 5D12.2

clone 5D12.2, Upstate®, from mouse

DCR1, Dicer, HERNA, KIAA0928

Quality Level

100

생물학적 소스

mouse

항체 형태

purified antibody

antibody product type

primary antibodies

클론

5D12.2, monoclonal

species reactivity

human

포장

antibody small pack of 25 μL

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

동형

IgG1κ

NCBI 수납 번호

NP_085124.2

UniProt 수납 번호

Q9UPY3

배송 상태

ambient

Gene Information

human ... DICER1(23405)

RNA interference (RNAi) is mechanism for post-transcriptional gene silencing that leads to the loss of the activity of the gene. RNAi is activated when long dsRNAs are cleaved by the enzyme Dicer1 (RNase III family of dsRNA-specific endonucleases) into 21-23 nucleotide siRNA (small interfering RNA). These siRNAs bind proteins to form the RISC (RNA-induced silencing complex) which is activated when the double stranded siRNAs are unzipped to single stranded siRNAs. Activated RISC recognizes and binds complementary sequences in mRNA. The mRNA is cleaved and the overall effect is an inhibition of the protein expression and a loss of the gene activity. Dicer1 along with the Argonaute family of proteins (Ago1 and Ago2) share the same domain PIWI and PAZ domain that provide endonuclease activity to RNA-induced silencing complexes (RISC).