Merck Anti-NFκB p50 Antibody

Anti-NFκB p50 Antibody

Source: Rabbit
Purification: Affinity chromatography

Target Description

Nuclear factor NF-kappa-B p105 subunit (UniProt P19838) — also known as DNA-binding factor KBF1, EBP-1, NF-kappa-B, NF-kappaB, NF-kB1, NFkappaB, NFKB-p105, NFKB-p50, Nuclear factor NF-kappa-B p50 subunit, Nuclear factor kappa-B DNA binding subunit, and Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 — is encoded by the NFKB1 gene (Gene ID 4790) in humans.

NF-κB is a protein complex that plays a key role in regulating the immune response to infection and inflammation. NF-κB1 is synthesized as a 968 amino acid protein (p105), which undergoes posttranslational processing to generate the p50 subunit (a.a. 1–433).

The p50 NF-κB participates in target gene transactivation by forming heterodimers with RelA, RelB, or c-Rel. Additionally, the p50 homodimer can bind the nuclear protein Bcl-3 and form a functional transcriptional activator complex.

In unstimulated cells, NF-κB dimers are sequestered in the cytoplasm by the family of IκB (Inhibitor of κB) proteins (IκBα, IκBβ, IκBε, and Bcl-3). Upon stimulation, IκB becomes phosphorylated by the IκB kinase (IKK) complex, leading to IκB ubiquitination and proteasomal degradation. With the degradation of IκB, the NF-κB complex is freed to enter the nucleus to activate transcription of target genes.

Specifications