Merck Anti-eIF-4E

Anti-eIF-4E

from rabbit, purified by affinity chromatography

Eukaryotic translation initiation factor 4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein

생물학적 소스

rabbit

Quality Level

100

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

polyclonal

정제법

affinity chromatography

species reactivity

mouse, human, rat

species reactivity (predicted by homology)

monkey (based on 100% sequence homology)

포장

antibody small pack of 25 μg

technique(s)

immunocytochemistry: suitable
western blot: suitable

동형

IgG

NCBI 수납 번호

NP_001124150

UniProt 수납 번호

P06730

배송 상태

ambient

Gene Information

human ... EIF4E(1977)

Eukaryotic translation initiation factor 4E (UniProt: P06730; also known as eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein) is encoded by the EIF4E (also known as EIF4EL1, EIF4F) gene (Gene ID: 1977) in human. elF-4E is a cytoplasmic factor that recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. It is a component of the CYFIP1-EIF4E-FMR1 complex that binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex. Three isoforms of elf-4E have been described that are generated by alternative splicing. Elf-4E contains four 7-methylguanosine-containing mRNA cap binding regions and three EIF4EBP1/2/3 binding regions. Hypophosphorylated EIF4EBP1, EIF4EBP2, and EIF4EBP3 are shown to compete with EIF4G1/EIF4G3 to interact with elF-4E. Phosphorylation of ElF4EBP1 by insulin-stimulated MAP kinase (MAPK1 and MAPK3) cause dissociation of the complex and allows EIF4G1/EIF4G3 to bind and result in initiation of translation. Mutations in ElF4E gene have been linked to autism with impairments in social interaction and communication and developmental abnormalities.