Merck Anti-eIF-4E

Anti-eIF-4E

from rabbit, purified by affinity chromatography

Eukaryotic translation initiation factor 4E (eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein)

생물학적 소스

rabbit

품질 등급

100 (M-Clarity Program)

항체 정보

반응 종

적용 기술

• Immunocytochemistry: suitable
• Western blot: suitable

NCBI 수납 번호

NP_001124150

UniProt 수납 번호

P06730

배송 상태

ambient

Gene Information

human ... EIF4E (1977)

Eukaryotic translation initiation factor 4E (UniProt: P06730; also known as eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein) is encoded by the EIF4E (also known as EIF4EL1, EIF4F) gene (Gene ID: 1977) in humans.
eIF-4E is a cytoplasmic factor that recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in protein synthesis initiation. It facilitates ribosome binding by inducing unwinding of secondary mRNA structures.

It is a component of the CYFIP1–EIF4E–FMR1 complex that binds to the mRNA cap and mediates translational repression. Three isoforms of eIF-4E are generated by alternative splicing.
The protein contains four 7-methylguanosine-binding regions and three EIF4EBP1/2/3 binding regions. Hypophosphorylated EIF4EBP1/2/3 compete with EIF4G1/3 to interact with eIF-4E. Phosphorylation of EIF4EBP1 by insulin-stimulated MAP kinases (MAPK1 and MAPK3) causes dissociation of the complex, allowing EIF4G1/3 binding and initiation of translation.

Mutations in the EIF4E gene have been linked to autism spectrum disorders with social and communication impairments and developmental abnormalities.