Merck Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

Upstate®, from rabbit

CD340 antigen, MLN 19, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, c-erb B2/neu protein, neuroblastoma/glioblastoma derived oncogene homolog, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma der

생물학적 소스

rabbit

Quality Level

100

항체 형태

affinity purified immunoglobulin

antibody product type

primary antibodies

클론

polyclonal

정제법

affinity chromatography

species reactivity

rat, human

포장

antibody small pack of 25 μL

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
western blot: suitable

동형

IgG

NCBI 수납 번호

NM_004448

UniProt 수납 번호

P04626

배송 상태

ambient

The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments.