Merck Anti-MEGF9 antibody produced in rabbit

Anti-MEGF9 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies

Affinity isolated antibody, buffered aqueous glycerol solution

Synonyms

• Anti-Multiple epidermal growth factor-like domains 9 precursor
• Anti-Multiple EGF-like domain protein 5
• Anti-EGF-like domain-containing protein 5

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Gene Information

Human MEGF9 (1955)
The gene MEGF9 (multiple epidermal growth factor-like domains 9) encodes a transmembrane protein containing multiple EGF-like repeats. The N-terminus contains several potential O-glycosylation sites followed by five EGF-like domains. It also contains a single-pass transmembrane domain followed by a highly conserved short intracellular domain with potential phosphorylation sites.

The mRNA is expressed in both developing and adult CNS (central nervous system) and PNS (peripheral nervous system), particularly in Purkinje cells of the cerebellum and glial cells of the PNS. Expression is also observed to some extent in the epidermal layer of skin, papillae of the tongue, and the epithelium of the gastrointestinal tract.

The gene is mapped to human chromosome 9q32–9q33.3 and consists of six exons spanning 113.66 kb.

• Exon 1: Signal peptide sequence and N-terminal domain
• Exons 2–5: Encode EGF-like repeats 1–5
• Exon 6: Encodes transmembrane region and cytoplasmic tail
• Exon 6 also includes a long untranslated region (4326 bp) and a conserved polyadenylation site.