Merck Anti-α-Tubulin antibody, Mouse monoclonal

Anti-α-Tubulin antibody, Mouse monoclonal

Clone Information

• Clone: B-5-1-2
• Type: Monoclonal, IgG1 isotype
• Source: Mouse hybridoma cell culture
• Form: Buffered aqueous solution
• Conjugation: Unconjugated
• Concentration: ~2 mg/mL

Quality Level

200 (M-Clarity Program)

Biological Source

Mouse

Antibody Product Type

Primary antibody

Molecular Weight

Antigen: ~50 kDa

Species Reactivity

Chicken, Kangaroo rat, Sea urchin, Rat, Chlamydomonas, Bovine, Human, African green monkey, Mouse

Enhanced Validation

Independent (Antibodies)
Learn more about Antibody Enhanced Validation

Techniques

UniProt Accession

P68366

Applications

Research pathology

Shipping and Storage

• Shipping: Dry ice
• Storage: −20°C

Gene Information

Description

α-Tubulin, also known as tubulin α4a (TUBA4A), is located on human chromosome 2q35 and encodes a 448-amino-acid protein belonging to the α-tubulin family. It forms part of the tubulin subfamily, the principal component of microtubules.
Monoclonal Anti-α-Tubulin (mouse IgG1) is derived from hybridoma B-5-1-2, produced by fusion of mouse myeloma cells and splenocytes from mice immunized with Sarkosyl-resistant filaments from Strongylocentrotus purpuratus (sea urchin).
Tubulin is a heterodimer composed of α- and β-tubulin, each with a molecular weight of approximately 50 kDa and high sequence homology. Several distinct tubulin classes exist, each with unique subcellular localization and functions. Microtubules, cylindrical filamentous structures found in nearly all eukaryotic cells, serve as structural and motile elements in mitosis, intracellular transport, flagellar movement, and cytoskeletal organization.
Microtubular systems contain at least three α-tubulin isoforms, two of which are encoded by separate α-tubulin genes producing highly similar proteins, while the third isoform arises via post-translational modification.

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