Thermo Fisher Scientific Phospho-Huntingtin (Ser421) Polyclonal Antibody
인간 및 생쥐 시료에서 Huntingtin 단백질의 Ser421 인산화형을 검출하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도 친화 크로마토그래피 정제 제품입니다. PBS/BSA 버퍼에 보관되며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Phospho-Huntingtin (Ser421) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1:100 – 1:200 |
| Immunocytochemistry (ICC/IF) | 1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide conjugated to KLH corresponding to residues GGRSRSG(pS)IVELI (414–426) of Human HTT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.24 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539854 |
Product Specific Information
PA1-087 has been successfully used in immunofluorescence, immunohistochemistry, and Western blotting applications on human and mouse samples.
Target Information
Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This condition is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, resulting in a polyglutamine repeat in the protein. HD manifests as a mid-life onset autosomal dominant neurodegenerative disease associated with psychiatric disorders, dementia, and involuntary movements (chorea), typically leading to death within 10–20 years.
The huntingtin locus spans approximately 180 kb and contains 67 exons. The gene is widely expressed and essential for normal development. It produces two alternatively polyadenylated transcripts (~13.7 kb and ~10.3 kb), with the larger transcript predominantly expressed in brain tissues and the smaller more widely expressed. The genetic defect may alter mRNA or protein function rather than abolish transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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