Thermo Fisher Scientific CMG2 Polyclonal Antibody
CMG2 단백질을 표적하는 Thermo Fisher Scientific의 염소 다클론 항체로, WB, Flow Cytometry, ELISA에 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 동결건조 형태로 제공되며, -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
| ELISA | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2 isoform 1 (Gln34–Asn317) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608422 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant mouse CMG-2 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin. ATR2/CMG2 is a type I membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. ATR2/CMG2 binds to protective antigen (PA), one of the three monomeric proteins released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol.
Mutations in the ATR2/CMG2 gene result in inhibition of binding by the VWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF). These are rare stiff-skin syndromes characterized by hyaline deposition in various organs, especially the skin and gingiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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