Thermo Fisher Scientific CLEC12A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunocytochemistry (ICC/IF)

5-15 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A isoform a Thr67-Ala265 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLEC12A,uniProtId:Q5QGZ9-2,ncbiNodeId:9606,antigenRange:67-265,antigenLength:265,antigenImageFileName:PA5-47423_CLEC12A_Q5QGZ9-2_Goat.svg,antigenImageFileNamePDP:PA5-47423_CLEC12A_Q5QGZ9-2_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607504

Product Specific Information

In Western blots, approximately 15% cross-reactivity with recombinant mouse MICL is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

CD371 is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.