ELK Biotechnology CKAP5 rabbit pAb

CKAP5 rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin.
Located to spindle poles and microtubules during mitosis.
In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase.
In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles.
Accumulation sites at microtubule plus ends protruded approximately 100 nm from MAPRE1/EB1 sites in interphase cells.

Background

This gene encodes a cytoskeleton-associated protein belonging to the TOG/XMAP215 family.
The N-terminal half contains a microtubule-binding domain, and the C-terminal half contains a KXGS motif for tubulin dimer binding.
It plays two distinct roles in spindle formation: protecting kinetochore microtubules from depolymerization and supporting centrosomal microtubule assembly.
It may also be essential for microtubule–cell cortex interactions during directional cell movement.
Additionally, it is involved in translation of myelin basic protein (MBP) mRNA through interaction with hnRNP A2.
Alternatively spliced transcript variants encoding different isoforms have been identified. (RefSeq, Aug 2011)