Thermo Fisher Scientific ING4 Polyclonal Antibody

Thermo Fisher Scientific ING4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ING4.

Target Information

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors.
All five members of the ING protein family contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure.

ING proteins form transcriptional complexes that activate responsive genes mediating:

• Growth arrest
• DNA repair
• Gene transcription
• Apoptosis
• Senescence

The candidate tumor suppressor ING4 plays a role in brain tumor pathogenesis and regulates tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, correlating with tumor progression. ING4 interacts with the p65 (RelA) subunit of NF-κB and represses transcription of NF-κB responsive genes. Inactivating mutations and deletions in ING4 have been described in various cancer cell lines, including 10–20% of human breast cancer cell lines and tumors.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.