Thermo Fisher Scientific Phospho-PDE6 gamma (Thr22) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of PDE6G only when phosphorylated at Thr22.

Target Information

The second messengers cAMP and cGMP are key regulatory molecules involved in diverse signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis via cyclic nucleotide phosphodiesterases (PDEs).

PDE6 acts as the effector enzyme in the G protein-mediated visual signal transduction cascade. It consists of several subunits: cone-specific catalytic subunit alpha′, rod-specific catalytic subunits alpha and beta, inhibitory subunit gamma, and subunit delta of unknown function.

The catalytic core comprises alpha′/alpha′ homodimers in cones and alpha/beta heterodimers in rods. The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, essential for proper complex assembly and membrane association.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.