Thermo Fisher Scientific Phospho-SMAD1/SMAD5/SMAD9 (Ser463, Ser465) Polyclonal Antibody
SMAD1/5/9 단백질의 Ser463 및 Ser465 인산화 부위를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 분석에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. -20°C에서 보관하며 연구용으로 사용.
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- PA5106037
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMAD1 (Accession Q15797), corresponding to amino acid residues around phosphorylated Ser465. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817436 |
Product Specific Information
This antibody detects endogenous levels of Smad1/5/9 only when phosphorylated at Ser463 and Ser465.
Target Information
The SMAD1/SMAD5/SMAD8/SMAD9 proteins belong to the SMAD family, which are signal transducers and transcriptional modulators mediating multiple signaling pathways. These proteins mediate bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1/5/9 are phosphorylated and activated by BMP receptor kinases, forming complexes with SMAD4 for transcriptional regulation. They are targets for SMAD-specific E3 ubiquitin ligases such as SMURF1 and SMURF2, leading to ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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